New York Yankees Favored To Win Wednesday Over San Diego

Chris Wassel
By , Updated on: May 7, 2025 12:00 AM
OSB New York Yankees Favored To Win Wednesday Over San Diego
  • When: Wednesday, May 7th at 7:05 PM ET
  • Who: San Diego Padres vs New York Yankees
  • TV/Streaming: MLB Net and Prime Video
  • Starting Pitchers: Dylan Cease and Max Fried
  • Where: Yankee Stadium, in Bronx, NY

The New York Yankees bounced back with a big win on Tuesday night as they routed the San Diego Padres. New York used the long ball and scored 10 runs in the seventh inning on the way to their 20th win of the young season. Now, that helped the Yankees improve to 12-8 at home. Padres vs Yankees bets examine what has gone on in this series.

The Yankees have been favorites in every game this series and Wednesday night is no exception. In this rubber match, New York sends its ace arguably while San Diego tries to reignite one of their top pitchers. Dylan Cease has A+ stuff and no results while Max Fried has been A++ in seven starts this year.

Do not forget to check out our MLB Betting Strategies Guide, which will help you prepare for any MLB props and wagers you may be interested in. San Diego had been streaking. They had won six consecutive contests before New York struck lightning in a bottle on Tuesday night. This rubber match may be more important for New York than for San Diego. Now, the Yankees are in first place only because the rest of the division is struggling. For perspective, Baltimore hit the 20 loss mark already on Monday night.

Meanwhile, with a jammed division, that does mean every game has a little added pressure. More is expected of the Yankees at this juncture. Even with some injuries, New York is underperforming by their standards.

Game Preview And Tables

The Padres vs Yankees bets is focused on two main wagers. Yes, the moneyline and the run total are first and foremost on our minds. Below, we have the following table.

MLB Wednesday Night Bovada BetOnline BetUS
San Diego Padres +150 +155 +160
New York Yankees -180 -190 -190
Over 7.5 Runs -115 -118 -120
Under 7.5 Runs -105 -102 EVEN

While the Padres have the better overall record, there are few places quite like Yankee Stadium. It is one of those venues where the record almost does not matter from the home team. For New York fans and bettors, the Yankees are over .500. There is that. Like we mentioned above, the Yankees are fortunate to have Max Fried on the mound. Injuries were unkind to New York in Spring Training. Without Gerrit Cole, pitching has been a struggle.

Someone already asked what about the NRFI (No Run First Inning). Let us get that out of the way first. The thought process is that Cease gives up a run or two early. Fried might only because at some point he cannot sustain a 1.01 ERA forever, right?

San Diego and New York To score 1+ runs on Wednesday
Bovada
EVEN

Padres vs Yankees Bets Favor The Home Team

Despite San Diego being 9-8 away from home, one gets the feeling that their road record is just not very impressive. New York getting up to 12-8 while overall 20-16 leaves them much more work to do. The Yankees are expected to win around 100 games in 2025. Losing three straight games before that big Tuesday night win was a jolt. If one believes the Yankees are going to score a run in the first inning, then it may not be a bad idea to go for the three-way after one inning. That pays out at a very good +245.

After not going six innings or more in his last five starts, Cease will come in trying to throw more strikes. Honestly, that may help the Yankees. New York is already motivated and Cease will be trying just to survive especially early on. It is a game which figures to favor the home team.

Betting on a home team going for an important series win is a good trend, and it's particularly confident here given the Padres are heading home after this. Yes, that is called good betting management. Expect Fried and the Yankees to come away with winning two of three from San Diego.

New York Yankees To beat the San Diego Padres Wednesday
Bovada
-180

We want to ensure you maximize the best bonuses and current promotions. These bonuses significantly increase your bankroll, allowing you to bet with house money!

Total Runs With San Diego And New York

The total runs with San Diego and New York is interesting too. With a low 7.5 total here, that makes it easy to try and tempt fate with the over. Also, do not forget that the Yankees only need five runs to get to a team total of 4.5 runs which now comes in at +110 via BetUS. This may not be a number which is seen for long.

Their 5.42 runs per game is one of the best in the American League. The Yankees do tend to have plenty of outbursts from a run-scoring standpoint. However, there is that fear where Cease could pitch like the two previous starters against the Yankees. However, the Padres' bullpen has to be tired after getting lit up in the seventh inning on Tuesday night.

Undoubtedly, the San Diego Padres have a pretty solid offense of their own. The Padres average four runs a game and slightly warmer conditions are expected for Wednesday evening. While it will not be a heat wave, temperatures near 70 degrees will feel more pleasant than what has been experienced since last weekend.

Overall, I'd take over 7.5 runs at -115 odds at Bovada. Do not worry as there are plenty more props which will open up between now and game time on Wednesday. Do not forget the Yankees race to four runs is also +110 via BetUS. Let's get at it!

San Diego and New York To score 8+ runs on Wednesay
Bovada
-115

Check our top online sportsbook reviews for the best odds on your favorite MLB games before placing your bets.

Meet the author

Chris Wassel

Chris Wassel AA, AAS CURRENTLY Sports Writer and Journalist RESIDES IN Rahway, NJ EDUCATION Union County College, Montclair State University EXPERTISE Business, Writing, Sports, Food, Grilling, Olympics, Injuries, Politics, and Baking Cookies Summary A long s...

Related content for you
Best Online Sports Betting
MLB
Dover Downs
Caesars Palace

Online Sports Betting may receive compensation if you sign up through our links. Rest assured, we avoid biases and provide honest opinions on sportsbooks. Read our disclosure here.